Health: General information about the drug therapy for depression

Depressed patients can be treated with drugs that act on the psyche. Because they directly opposite (Latin: anti) act depressive disorders, it is also called antidepressants (singular: antidepressant). To treat depression, a large number of drugs are available. If a patient is suffering from moderate or severe depression, its treatment may consist of a combination of medication and psychotherapy.

According to some studies, the risk of stroke and other causes of death may be increased by certain drug therapies. Prior to initiation of drug therapy risks and benefits should always be weighed against each other. Normally, the drugs put on the brain metabolism. Here they cause a change in certain metabolic processes between nerve cells.
The main active ingredient groups are listed below:

• Classical antidepressants (act depending on exact type of medication mood enhancing, soothing or drive-enhancing)
• Reuptake inhibitors (increase the concentration of chemicals in the brain that counteract the depression)
• Inhibitors (prevent the breakdown of neurotransmitters in the brain that counteract the depression)
• Herbal antidepressants

Classical antidepressants

To the group of classical antidepressants include tricyclic and tetracyclic antidepressants.

Tricyclic antidepressants, such as amitriptyline and clomipramine, acting in several systems of the brain metabolism. You increase the drive, lift your mood and have a calming effect.

The administration of tricyclic antidepressants may be accompanied by numerous side effects. A dose of tricyclic antidepressants in patients with the following underlying conditions leads to an increased risk:

• Dementia
• Angle-closure glaucoma (a type of glaucoma)
• Benign prostate enlargement
• Seizures
• Severe constipation
• Cardiovascular disease
• Confusion
• Strictures in the gastrointestinal tract
• Reuptake inhibitors

In order to alleviate side effects, requires the development of modern drugs directly to their effect on individual (selective) chemical messengers of the brain. However, you do not have the antidepressant effect as the tricyclic antidepressants. The messengers, called neurotransmitters, are used to connect or transmission between nerve cells. Normally, the nerve cell secretes a chemical messenger in the cell gap (synaptic cleft).

This leads to a stimulation of the target cell. Depending on the nature of the messenger substance, different reactions are caused in the target cell. About specific mechanisms of neurotransmitter is finally removed from the cell gap. Here is the starting point of the above group of drugs. If, medication slowed the resumption of chemical mediators that can counteract depression, the messenger can work longer and thus compensate for the deficiency, which leads to the symptoms of depressive disorders.

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